NLRP13 Products

Description

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP13, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM]

Bioinformatics

Uniprot	AAI48743.1 Human EAW72420 Human
Product By Gene ID	126204
Alternate Names	CLR19.7 leucine rich repeat and pyrin domain containing 13 NACHT, leucine rich repeat and PYD containing 13 NACHT, LRR and PYD containing protein 13 NACHT, LRR and PYD domains-containing protein 13 NALP13 NLR family, pyrin domain containing 13 NOD14 nucleotide-binding oligomerization domain protein 14 PAN13