Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Rabbit Polyclonal
Species: Hu
Applications: IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP13, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM]
Bioinformatics
Uniprot |
Human Human |
Product By Gene ID |
126204 |
Alternate Names |
- CLR19.7
- leucine rich repeat and pyrin domain containing 13
- NACHT, leucine rich repeat and PYD containing 13
- NACHT, LRR and PYD containing protein 13
- NACHT, LRR and PYD domains-containing protein 13
- NALP13
- NLR family, pyrin domain containing 13
- NOD14
- nucleotide-binding oligomerization domain protein 14
- PAN13
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