NLRP1/NALP1 Products

Description

NALP1 (also known as NAC/CARD7) is a member of the CATERPILLER (CLR) diverse multigene superfamily of immune regulatory proteins (Ting and Davis, 2005). CLR proteins have a variable N-terminal domain, followed by a nucleotide-binding domain (NBD) and leucine-rich repeats (LRR). The N-terminal domain consists of transactivation, CARD, Pyrin or BIR domains, or in some cases is undefined. The CLR family, also known as the NOD family, has its ancient roots in the plant kingdom and is related to the disease resistance (R) gene family that mediates plant immune responses. CLR proteins participate in both innate and adaptive immunity in mammals, some act as sensors that detect pathogen products, and several CLR genes have been linked to susceptibility to immunological diseases. It is thought that the CLR family may have a fundamental importance for the function of the mammalian innate/ancient immune system on par with the Toll-like receptor (TLR) family. NALP1, a member of NALP CLR subfamily, has an N-terminal pyrin domain (PYD), followed by an NBD, LRR, and a C-terminal CARD domain (reviewed in Tschopp. NALP1 is a component of both the inflammasome and apoptosome, suggesting that NALP1 it has important roles in both inflammation and apoptosis. This antibody recognizes NALP1; human NALP1 is a 1473 amino acid protein and migrates at approx. 166 kDa on SDS-PAGE. However, multiple splice variants encoding distinct NALP1 isoforms with varying amino acid lengths have been described and thus the molecular weight detected may vary depending on the isoform(s) expressed.

Bioinformatics

Uniprot	AAG30288 Human NM_033004 Human NP_055737 Human NP_055737.1 Human Q9C000 Human
Product By Gene ID	22861
Alternate Names	CARD7SLEV1 Caspase recruitment domain-containing protein 7 CLR17.1 Death effector filament-forming ced-4-like apoptosis protein DEFCAPVAMAS1 DKFZp586O1822 KIAA0926DEFCAP-L/S NACHT, leucine rich repeat and PYD (pyrin domain) containing 1 NACHT, leucine rich repeat and PYD containing 1 NACHT, LRR and PYD containing protein 1 NACHT, LRR and PYD domains-containing protein 1 NACPP1044 NALP1caspase recruitment domain protein 7 NLR family, pyrin domain containing 1 Nucleotide-binding domain and caspase recruitment domain nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 1

Research Areas for NLRP1/NALP1

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Apoptosis

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Pyroptosis: Mechanisms mediating cell death and pro-inflammatory cytokine release By Victoria OsinskiPyroptosis is an inflammatory form of programmed cell death characterized by the release of pro-inflammatory cytokines IL-1 beta and IL-18.1,10 It is a process distinct from apoptosis and necrosis (T...    Read more.

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