Species: Hu
Applications: WB, IHC, IP, B/N, KO
Host: Mouse Monoclonal
Species: Hu
Applications: WB, IHC, ELISA(Cap), KO
Host: Goat Polyclonal
Species: Hu, Mu
Applications: WB, ELISA, Flow, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Mu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: Enzyme Activity
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE
Description
Human interstitial collagenase (matrix metalloproteinase-1, MMP-1), an enzyme whose only known physiologic substrate has heretofore been believed to be the extracellular matrix molecule, collagen. Data indicate that matrix metalloproteinase-1 displays an expanded substrate repertoire that supports the existence of a new interface between connective tissue turnover and serine proteinase inhibitors (1). It has been shown that the MMP-1 functions as a protease agonist of Protease-activated receptors (PAR1) cleaving the receptor at the proper site to generate PAR1-dependent Ca2+ signals and migration. These results demonstrate that MMP-1 in the stromal-tumor microenvironment can alter the behavior of cancer cells through PAR1 to promote cell migration and invasion (2). It has also been suggested that increased levels of MMP-1 due to tobacco smoking plays a major role in the aging process of skin since MMP-1 degrades collagen, which accounts for at least 70% of the dry weight of dermis. Significantly more MMP-1 has been detected in the skin of smokers than non-smokers whereas no difference was seen for the tissue inhibitor of metalloproteinases 1 (3).
Bioinformatics
Entrez |
Human Rat |
Uniprot |
Human Human Human Human Human |
Product By Gene ID |
4312 |
Alternate Names |
- CLGmatrix metalloprotease 1
- CLGN
- EC 3.4.24
- EC 3.4.24.7
- Fibroblast collagenase
- interstitial collagenase
- matrix metallopeptidase 1 (interstitial collagenase)
- matrix metalloproteinase 1 (interstitial collagenase)
- Matrix metalloproteinase-1
- MMP-1
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