Matriptase/ST14 Products

Description

ST14 is encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.

Bioinformatics

Entrez	6768 Human
Uniprot	NP_068813 Human Q8WVC1 Human Q9Y5Y6 Human
Product By Gene ID	6768
Alternate Names	EC 3.4.21 HAI Matriptase Membrane-type serine protease 1 MT-SP1EC 3.4.21.109 prostamin Prostamin PRSS14 Serine protease 14 Serine protease TADG-15 SNC19MTSP1 suppression of tumorigenicity 14 (colon carcinoma) suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin) suppressor of tumorigenicity 14 protein TADG15 TMPRSS14 tumor associated differentially expressed gene 15 protein Tumor-associated differentially-expressed gene 15 protein

Research Areas for Matriptase/ST14

Find related products by research area and learn more about each of the different research areas below.

Cancer