MALT1 Products

Description

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), also known as MLT1 or paracaspase 1, is a member of the human paracaspase family and an interacting partner of B-cell lymphoma 10 (Bcl-10) (1). In vitro, In vitro, MALT1 synergizes with BCL10 to enhance nuclear factor B activation (2) and to mediate IB kinase (IKK) activation by facilitating the ubiquitinylation of the NF-B essential modulator (NEMO) (3). MALT1 is found in recurrent chromosomal translocations in non-Hodgkin B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT). One common translocation juxtaposes the MALT1 gene to the IgH promoter region, resulting in up-regulation of Bcl-10 and MALT1 (4). Another common translocation creates a fusion between MALT1 and the inhibitor of apoptosis gene API2 (cIAP2/HIAP1) (5).

Bioinformatics

Entrez	10892 Human 240354 Mouse 307366 Rat
Uniprot	AAH30143 Human NM_006785 Human NP_776216 Human NP_776216.1 Human
Product By Gene ID	10892
Alternate Names	caspase-like protein DKFZp434L132 EC 3.4.22.- MALT associated translocation MALT lymphoma-associated translocation MLT1 MLTMALT-lymphoma associated translocation mucosa associated lymphoid tissue lymphoma translocation gene 1 mucosa-associated lymphoid tissue lymphoma translocation protein 1 paracaspase Paracaspase

Research Areas for MALT1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Tumor Suppressors