Species: Hu
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, IHC, IP
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
Human
Human
|
| Product By Gene ID |
3115 |
| Alternate Names |
- DP beta 1 chain
- DPB1
- HLA class II histocompatibility antigen, DP(W4) beta chain
- HLA DP14-beta chain
- HLA-DP histocompatibility type, beta-1 subunit
- HLA-DP1B
- HLA-DPB
- major histocompatibility complex class II HLA DPB1 protein
- major histocompatibility complex, class II, DP beta 1
- MHC class II antigen beta chain
- MHC class II antigen DP beta 1 chain
- MHC class II antigen DPB1
- MHC class II antigen DPbeta1
- MHC class II HLA-DP-beta
- MHC HLA DPB1
|
