DPP6 Products

Description

The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.

Bioinformatics

Entrez	1804 Human
Uniprot	NP_001034439 Human NP_001927 Human P42658 Human
Product By Gene ID	1804
Alternate Names	dipeptidyl aminopeptidase IV-related protein dipeptidyl aminopeptidase-like protein 6 Dipeptidyl aminopeptidase-related protein Dipeptidyl peptidase 6 Dipeptidyl peptidase IV-like protein dipeptidyl peptidase IV-related protein Dipeptidyl peptidase VI dipeptidylpeptidase 6 dipeptidyl-peptidase 6 dipeptidylpeptidase VI DPP VI DPPXFLJ55680 MGC46605 VF2

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