Dectin-1/CLEC7A Products

Description

Dectin1 encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

Bioinformatics

Entrez	64581 Human
Uniprot	AAH13385 Human EAW96155 Human NP_922938 Human NP_922941 Human NP_922945 Human Q6QLQ4 Mouse Q9BXN2 Human
Product By Gene ID	64581
Alternate Names	Beta-glucan receptor BGR CLECSF12DC-associated C-type lectin 1 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamilymember 12 C-type lectin domain family 7 member A C-type lectin domain family 7, member A C-type lectin superfamily member 12 Dectin-1 dectin-1 DECTIN1CANDF4 Dendritic cell-associated C-type lectin 1 dendritic cell-associated C-type lectin-1 hDectin-1 lectin-like receptor 1

Research Areas for Dectin-1/CLEC7A

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Signal Transduction

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