DCTN3 Products

Description

DCTN3 encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq]

Bioinformatics

Entrez	11258 Human 362504 Rat 53598 Mouse
Uniprot	AAH00319 Human NM_007234 Human NM_024348 Human NP_009165.1 Human NP_077324 Human NP_077324.1 Human O75935 Human
Product By Gene ID	11258
Alternate Names	DCTN22DCTN-22 dynactin 3 (p22) dynactin 3 Dynactin complex subunit 22 kDa subunit dynactin light chain dynactin subunit 3 MGC111190 p22

Research Areas for DCTN3

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Cell Cycle and Replication