CHREBP Products

Description

ChREBP is a transcription factor involved in activating genes that encode enzymes of fatty acid biosynthesis in liver and adipose. The ChREBP protein binds and activates the carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. ChREBP may also play roles in lipid metabolism, obesity, and type II diabetes.

The CHREBP protein is missing in the multisystem developmental disorder, Williams-Beuren syndrome. CHREBP antibodies are useful tools for studying lipid and fatty acid metabolism.

Bioinformatics

Entrez	171078 Rat 51085 Human 58805 Mouse
Uniprot	NP_116569 Human NP_116569.1 Human Q9NP71 Human
Product By Gene ID	51085
Alternate Names	BHLHD14 CHREBPcarbohydrate-responsive element-binding protein Class D basic helix-loop-helix protein 14 MIOWS basic-helix-loop-helix leucine zipper protein MLX interacting protein-like MLX interactor MLX-interacting protein-like MONDOBWilliams-Beuren syndrome chromosomal region 14 protein WBSCR14Williams-Beuren syndrome chromosome region 14 protein 1 Williams Beuren syndrome chromosome region 14 Williams-Beuren syndrome chromosome region 14 protein 2 WS-bHLHbHLHd14carbohydrate response element binding protein

Research Areas for CHREBP

Find related products by research area and learn more about each of the different research areas below.

Cancer
Chromatin Research
DNA replication, Transcription, Translation and Splicing
Lipid and Metabolism
Transcription Factors and Regulators

Related CHREBP Blog Posts

Check out the latest blog posts on CHREBP.

ChREBP, a glucose sensitive transcription factor with role in glucose-lipids homeostasis and cancer ChREBP (carbohydrate response element-binding protein) is a glucose responsive basic helix-loop-helix/leucine zipper (bHLH/LZ) transcription factor that binds MLX and then carbohydrate response element /ChoRE for the induction of genes involved in ...    Read more.

ChREBP and Fatty Acid Biosynthesis Regulation Carbohydrate response element binding protein (ChREBP) is a transcription factor involved in activating genes that encode enzymes of fatty acid biosynthesis in liver and adipose. It is believed to be a key controller of hepatic lipogenesis and has a p...    Read more.

Insulin signaling in adipocytes: Carbohydrate-signaling transcription factor ChREBP is the link between lipolytic enzyme Hormone-Sensitive Lipase and lipogenic enzyme ELOVL6 By Jamshed Arslan, Pharm. D., PhD. Insulin resistance in adipocytes is a major feature of metabolic syndrome   . Disrupted adipose tissue metabolism can lead to accumulation of lipid intermediates in insul...    Read more.

Deficiency of GluT1 leads to neurological problems while excess is involved in cancers By Jamshed Arslan, Pharm. D., PhD. What Are GluTs?Mammalian cell metabolism is incomplete without glucose   . Glucose is a monosaccharide that is transported to the cells through facilitative diffusion, a ...    Read more.

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