Species: Hu, Mu, Rt, Ca, Pm, Pm
Applications: WB, Flow, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Sheep Polyclonal
Species: Hu, Mu
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
FUNCTION: GABARAPL1 (GABARAPL2 or GABARAP or MAP1LC3)-modifier protein conjugating enzyme involved in its E2-like covalent binding to PE. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3 (E2-like enzyme). Preferred substrate is MAP1LC3A. Formation of the GABARAPL1-PE conjugate is essential for autophagy. SUBUNIT: Interacts with ATG7 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. SUBCELLULAR LOCATION: Cytoplasm. ALTERNATIVE PRODUCTS: 2 named isoformsproduced by alternative splicing. TISSUE SPECIFICITY: Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta. SIMILARITY: Belongs to the ATG3 family.
Bioinformatics
| Entrez |
Rat
Human
Mouse
|
| Uniprot |
Human
Human
Human
Human
Human
Human
Human
Human
|
| Product By Gene ID |
64422 |
| Alternate Names |
- APG3 autophagy 3-like (S. cerevisiae)
- APG3
- APG3L
- APG3-like
- APG3-LIKE
- ATG3 autophagy related 3 homolog (S. cerevisiae)
- Autophagy-related protein 3
- DKFZp564M1178
- EC 6.3.2.-
- FLJ22125,2610016C12Rik
- hApg3
- MGC15201
- PC3-96
- Protein PC3-96
- ubiquitin-like-conjugating enzyme ATG3
|
Research Areas for ATG3/APG3
Find related products by research area and learn more about each of the different research areas below.
AutophagyCancerPhospho-Specific
