Aldehyde Dehydrogenase 1-A1/ALDH1A1 Products

Description

Usual human livers contain two major ALDH isozymes, i.e., cytosolic ALDH1 and mitochondrial ALDH2(1). Human red cell aldehyde dehydrogenase (ALDH) resembles the liver cytosolic isozyme in numerous physicochemical properties. Thus, the erythrocyte enzyme, by virtue of its chemical and structural identity with the liver cytosolic enzyme, may serve as a suitable peripheral enzyme model to understand the cause and mechanism of alcohol abuse-related changes in liver cytosolic ALDH that has been found to be reduced in alcoholics (2). ALDH1A1 is known to catalyze the oxidation of retinaldehyde to retinoic acid. Overexpression of human ALDH1A1 in HEK cells led to a more than 20-fold increase in 3-deoxyglucosone dehydrogenase activity (3).

Bioinformatics

Entrez	11668 Mouse 216 Human 24188 Rat
Uniprot	AAH01505 Human NM_000689 Human NP_000680 Human NP_000680.2 Human P00352 Human
Product By Gene ID	216
Alternate Names	acetaldehyde dehydrogenase 1 ALDC aldehyde dehydrogenase 1 family, member A1 aldehyde dehydrogenase 1, soluble Aldehyde dehydrogenase family 1 member A1 Aldehyde dehydrogenase, cytosolic aldehyde dehydrogenase, liver cytosolic ALDH class 1 ALDH1 ALDH11 ALDH-E1 ALHDII EC 1.2.1 EC 1.2.1.36 MGC2318 PUMB1 RALDH 1 RalDH1 RALDH1 retinal dehydrogenase 1 retinaldehyde dehydrogenase 1

Research Areas for Aldehyde Dehydrogenase 1-A1/ALDH1A1

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