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BID Products

Antibodies
BID Antibody [Unconjugated]
BID Antibody [Unconjugated]
Species: Hu, Mu
Applications: WB, Simple Western, IP
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
BID Antibody
BID Antibody
NB100-56106
Species: Hu, Mu, Rt, Ca, Ma
Applications: WB, IHC, IP
Host: Rabbit Polyclonal
BID Antibody (91508) [Unconju ...
BID Antibody (91508) [Unconjugated]
MAB860
Species: Hu, Mu
Applications: WB
Host: Rat Monoclonal
Formulation Catalog # Availability Price  
Antibody Pairs
BID Antibody Pair [HRP]
BID Antibody Pair [HRP]
NBP2-79468
Species: Hu
Applications: ELISA
Host: Mouse Monoclonal
Conjugate Catalog # Availability Size Price
ELISA Kits
Rat BID ELISA Kit (Colorimetr ...
Rat BID ELISA Kit (Colorimetric)
NBP2-69968
Species: Rt
Applications: ELISA
Mouse BID ELISA Kit (Colorime ...
Mouse BID ELISA Kit (Colorimetric)
NBP2-69967
Species: Mu
Applications: ELISA
Human BID ELISA Kit (Colorime ...
Human BID ELISA Kit (Colorimetric)
NBP2-69966
Species: Hu
Applications: ELISA
Lysates
BID Overexpression Lysate
BID Overexpression Lysate
NBL1-07979
Species: Hu
Applications: WB
BID Overexpression Lysate
BID Overexpression Lysate
NBP2-10076
Species: Hu
Applications: WB
Proteins
Recombinant Human BID (Caspas ...
Recombinant Human BID (Caspase-8-c...
882-B8
Species: Hu
Applications: Enzyme Activity
Formulation Catalog # Availability Price  
Recombinant Mouse BID (Caspas ...
Recombinant Mouse BID (Caspase-8-c...
883-M8
Species: Mu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Mouse BID Protein ...
Recombinant Mouse BID Protein, CF
860-MB
Species: Mu
Applications: Bioactivity
Formulation Catalog # Availability Price  

Description

The Bcl-2 family of apoptosis-related genes plays central roles in regulating apoptotic pathways (reviewed in Thomadaki and Scorilas, 2006). Regulation of cell death through apoptosis is critical for the maintenance of homeostasis, defense against infectious agents, and normal development. Bcl-2 family proteins regulate apoptosis primarily through the regulation of mitochondrial outer membrane permeability. In mammals, the family consists of both prosurvival (antiapoptotic) and proapoptotic (prodeath) members. Cellular homeostasis is thought to be dependent on a balance between the actions of prosurvival and proapoptotic proteins. Bcl-2 family proteins can be divided into 3 main subfamilies on the basis of their function and the content of their Bcl-2 homology (BH) domains, for example: 1) Prosurvival: Bcl-2, Bcl-XL, Bcl-W, A1, and Mcl-1 2) Proapoptotic (multidomain): Bax, Bak, and Bok. 3) BH3-only (proapoptotic): Bad, Bcl-XS, Bid, Bik, Bim, Blk, Bmf, Bnip, Noxa, and Puma. Prosurvival members inhibit cells from undergoing apoptosis, whereas proapoptotic and BH3-only subfamily members promote apoptosis. There are 4 BH domains (1-4) conserved among Bcl-2 family proteins. The BH domains are important for function as well as for heterodimerization between family members. Typical prosurvival family members have all four BH domains (1-4), whereas proapoptotic (multidomain) members have BH1, 2 and 3 domains and BH3-only members have only the BH3 domain. Overall, the relative ratio of prosurvival and proapoptotic proteins determines the suseptibility of a cell to various apoptotic stimuli. Many Bcl-2 family proteins are differentially expressed in various malignancies and some are useful prognostic biomarkers. Prosurvival proteins are often elevated in diverse cancers and have the potential to confer resistance to both endogenous cell death stimuli and cancer treatments. Alterations in the ratio or levels of Bcl-2 family proteins have been also associated with nonmalignant diseases including neurodegenerative diseases, autoimmune diseases, AIDs, Down's syndrome, cardiovascular diseases, diabetes, glomerulonephritis, and muscular dystrophy. IMG-5693 recognizes Bid (approx. 19-23 kDa) and cleaved/truncated forms of Bid. The C-terminal cleaved/truncated form (11-15 kDa) of Bid is often referred to as tBid in the literature (reviewed in Yin, 2006).

Bioinformatics

Entrez Mouse
Human
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Mouse
Human
Human
Human
Human
Human
Human
Human
Mouse
Product By Gene ID 637
Alternate Names
  • apoptic death agonist
  • BH3 interacting domain death agonist
  • BH3-interacting domain death agonist
  • BID isoform ES(1b)
  • BID isoform L(2)
  • BID isoform Si6
  • desmocollin type 4
  • FP497
  • Human BID coding sequence
  • MGC15319
  • MGC42355
  • p22 BID
  • tbid

Research Areas for BID

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Phospho-Specific
Tumor Suppressors

Related BID Blog Posts

Check out the latest blog posts on BID.
The role of p53 in UV radiation DNA damage and subsequent tumorogenesis
p53, the protein product of the tp53 gene, is one of the most widely studied tumor suppressor proteins in cancer research.  p53 is unique in that it demonstrates both tumor suppressive and tumor progressive properties depending on whether it is fu...    Read more.
The use of apoptosis antibodies and controls in cell death research
Apoptosis is a method of programmed cell death that is notably characterized by a morphological change in cellular nuclei and membrane appearance.  Not to be confused with necrosis, apoptosis is a pathway that is induced by a variety of factors tha...    Read more.
Apoptosis and Necroptosis Part I: Important factors to identify both types of programmed cell death
Different types of cell death have classically been identified by discrete morphological changes. The hallmarks of apoptosis include cell shrinkage, nuclear fragmentation and membrane blebbing whereas necroptosis is characterized by cell swelling ...    Read more.
Bcl-2 - an antiapoptotic protein with an important role in cancer cell survival
B-cell lymphoma 2 (Bcl-2) protein is an oncogene that normally acts as an apoptotic inhibitor and localizes to the mitochondrial membrane where it prevents the release of cytochrome c. The Bcl-2 protein family consists of over 20 proteins each co...    Read more.
active/cleaved Caspase 2 - Inducing apoptosis in response to cellular stress
Caspase-2 is a highly conserved member of the caspase family involved in the initiation and execution of apoptosis. While its function is still poorly understood, caspase-2 is thought to be important for apoptosis in response to DNA damage, bacteri...    Read more.
Read more BID related blogs.