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Description

The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) start site, and alternative, downstream, AUG translation initiation sites.

Bioinformatics

Entrez	573 Human
Uniprot	ENSP00000369026 Human NM_004323 Human NP_001165886 Human NP_004314 Human
Product By Gene ID	573
Alternate Names	BAG family molecular chaperone regulator 1 BAG-1 Bcl-2 associating athanogene-1 protein Bcl-2-associated athanogene 1 BCL2-associated athanogene Bcl-2-binding protein glucocortoid receptor-associated protein RAP46,46-KD HAP RAP46

Research Areas for Bag-1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Tumor Suppressors

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BAG3 - Hsp70 is my friend! The BAG proteins are a large family of chaperone regulators governing a wide range of cell processes such as proliferation, survival, stress response, tumorigenesis, neuronal differentiation, growth arrest and apoptosis as reviewed in Takayama et al1....    Read more.

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