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Jamshed Arslan

Signal Transducer and Activator of Transcription STAT6: More than a Player in Allergic Inflammation

STAT6 immunocytochemical staining of Daudi human Burkitt’s lymphoma cell line with rabbit anti-human phospho-STAT6 monoclonal antibody.

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
JAK
JAK1
JAK2
JAK3
TYK2
STAT1
STAT2
STAT3
STAT4
STAT5A
STAT5B
STAT6
IL-4
IL-13
gata-3
CCL11/Eotaxin
CCL17/TARC
CCL22/MDC
CCL26/Eotaxin-3
enolase-2
Jamshed Arslan

Understanding COVID-19 Through SARS-CoV-2-Infected Monkey Model

Learn more about how Laverne can help identifying SARS related genes and pathways.

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
Microbiology
virus
SARS-spike-protein
SARS-nucleocapsid-protein
COVID-19
SARS-CoV-2
Jamshed Arslan

Blocking SARS-CoV-2 Cell Entry: A potential Strategy Against COVID-19 Pandemic

Read the blog and learn more about SARS-CoV-2, an RNA virus from bats transmitted to human through an undetermined host specie and the causal agent of COVID-19.

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
Microbiology
virus
SARS-CoV-2
SARS-CoV
COVID-19
ACE-2
Camostat mesylate
tmprss2
Jamshed Arslan

Insulin signaling in adipocytes: Carbohydrate-signaling transcription factor ChREBP is the link between lipolytic enzyme Hormone-Sensitive Lipase and lipogenic enzyme ELOVL6

Fatty acid binding protein 4 (FAB4) is expressed in adipocytes where it activates hormone-sensitive lipase and helps regulate lipolysis.

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
ChREBP
Hormone-sensitive lipase
ELOVL6
Insulin
IRS1
Akt
Metabolic syndrome
Diabetes
Jamshed Arslan

Inhibiting incretin GIP hormone activity in mouse and monkey models to combat obesity

The release of insulin from pancreas beta-cells is controlled by glucose levels, Vagus nerve input, and GLP-1 from the intestines.

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
GIP
GIPR
GLIP1
GLIP-R
Obesity
Insulin
Metabolic syndrome
Jamshed Arslan

Insulin signaling in brain’s subfornical organ is crucial for regulating cardiometabolic profile

Learn about cardiovascular biology resources from Bio-Techne

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
Insulin
Insulin receptor
insulin-r-cd220
Cre
Cre recombinase
Metabolic syndrome
Jamshed Arslan

Muscle-specific UBE2O ablation requires activated AMPKα2 to protect against metabolic syndrome

Clearance of elevated glucose and fatty acids by skeletal muscle is affected by the development of insulin resistance.

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
Lipid and Metabolism
Heart Disease
Diabetes
metabolism
Metabolic syndrome
ampk-alpha-2
ampk-beta
ampk-gamma
UBE2O
ampk-alpha-1
acetyl-coa-carboxylase-alpha-acaca
tbc1d1
Jamshed Arslan

Metabolic Syndrome: Symptoms and associated disease states

The term, metabolism, refers to the totality of chemical reactions that occur in a biological system for the conversion of ingested nutrients into their basic constituents (i.e. proteins, lipids, nucleic acids and carbohydrates).
Tags: 
Lipid and Metabolism
Heart Disease
Diabetes
SREBP1
foxo1-fkhr
TNF-alpha
IL-6
adiponectin-acrp30
beta-3-adrenergic-r-adrb3
hormone-sensitive-lipase-hsl
glycogen-phosphorylase-muscle-form
Jamshed Arslan

Neurovascular signaling for repair enhances brain metastasis

High expression of GFAP (green) identifies astrocytes in rat cerebellum

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
Cancer
Neuroscience
Metastasis
IHC
Immunohistochemistry
Flow cytometry
PTEN
VEGF
Angiopoietin
MMP
TGF-beta
GFP
Melanoma
Astrocytes
mTOR
EPH
Semaphorin
PPAR
rxr-alpha-nr2b1
Jamshed Arslan

Glypican 3 as a biomarker for gastro-esophageal adenocarcinoma

Expression of CD81 was detected by immunofluorescence with a mouse monoclonal antibody followed by secondary antibody labeled with DyLight488 and Phalloidin 568 staining for actin visualization

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
Cancer
Western blot
Immunoblotting
Flow cytometry
Exosome Markers
Glypican 3
Glypican
TSG101
CD9
CD63
CD81
CEA
Carcinoembryonic antigen
CA 72-4
CA 19-9
Jamshed Arslan

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