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COVID-19 Pathology and Immune Response to SARS-CoV-2 Infection: Highlights from Studies at NIH, CDC, and Harvard

SARS-CoV-2 nucleocapsid protein is found in the core of the viral particle, interacts with viral RNA and functions in genome packing.

By Rosa Moreno, PhD.

Tags:

virology-bacteria-parasites

SARS-CoV-2 nucleocapsid protein

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Tiny Antibodies (VHHs) from Llama Neutralize Respiratory Coronaviruses

Sharks and llamas produce smaller antibodies called heavy chain-only antibodies (HCAbs) with a single variable domain, VHH.

By Jamshed Arslan, Pharm. D., PhD.

Tags:

virology-bacteria-parasites

SARS-spike-protein

sars-cov-2-spike-recombinant-protein

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Signal Transducer and Activator of Transcription STAT6: More than a Player in Allergic Inflammation

STAT6 immunocytochemical staining of Daudi human Burkitt’s lymphoma cell line with rabbit anti-human phospho-STAT6 monoclonal antibody.

By Jamshed Arslan, Pharm. D., PhD.

Tags:

CCL26/Eotaxin-3

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Migrasomes: A Novel Vesicle Involved in Intercellular Signaling

By Christina Towers, PhD

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Understanding Mitophagy Mechanisms: Canonical PINK1/Parkin, LC3-Dependent Piecemeal, and LC3-Independent Mitochondrial Derived Vesicles

By Christina Towers, PhD

Tags:

Selective Autophagy

Christina Towers

Understanding COVID-19 Through SARS-CoV-2-Infected Monkey Model

Learn more about how Laverne can help identifying SARS related genes and pathways.

By Jamshed Arslan, Pharm. D., PhD.

Tags:

SARS-spike-protein

SARS-nucleocapsid-protein

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Liver ASK1 activates autophagy to protect against hepatic fat accumulation, non-alcoholic steatohepatitis and fibrosis

MAP3K9 a MAP3K family member is expressed in the cytoplasm of human liver hepatocytes.

By Jamshed Arslan, Pharm. D., PhD.

Tags:

lipopolysaccharide

collagen-i-alpha-1

Blocking SARS-CoV-2 Cell Entry: A potential Strategy Against COVID-19 Pandemic

Read the blog and learn more about SARS-CoV-2, an RNA virus from bats transmitted to human through an undetermined host specie and the causal agent of COVID-19.

By Jamshed Arslan, Pharm. D., PhD.

Tags:

Camostat mesylate

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New Players in the Mitophagy Game

By Christina Towers, PhD

Tags:

Selective Autophagy

Adenine nucleotide translocase 1

Christina Towers

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Insulin signaling in adipocytes: Carbohydrate-signaling transcription factor ChREBP is the link between lipolytic enzyme Hormone-Sensitive Lipase and lipogenic enzyme ELOVL6

Fatty acid binding protein 4 (FAB4) is expressed in adipocytes where it activates hormone-sensitive lipase and helps regulate lipolysis.

By Jamshed Arslan, Pharm. D., PhD.

Tags:

Hormone-sensitive lipase

Metabolic syndrome

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