The NALP family consists of cytoplasmic proteins within the larger CATERPILLER protein family. There exist in short forms (such as NALP4) and long forms (NALP1). NALP proteins include the apoptosis regulator apoptotic protease activating factor 1 (APAF1) and mammalian NOD-LRR proteins, and are thought to play a role in the inflammation and reproduction processes. They play a key role in the formation of large signal-induced proinflammatory multiprotein complexes termed "inflammasomes", as published in a Nature Molecular Cell Biology 2003 review by Tschopp, more recently reviewed by Boaru1,2. NALP4 is also involved in modulating NF-kB activity.
Immunohistochemistry: NALP4 Antibody
Additionally, a comprehensive study by Assou’s group focused on early embryonic development found that many NALP family genes (NALP4, NALP5, NALP9, NALP11 and NALP13) are key biomarkers of trophectoderm (TE) cells and the steroidogenesis process3. A Japanese research group used the NALP4 antibody to demonstrate in interaction between several NALP family members and the autophagy regulator Beclin14. Their data provides novel evidence that NALP4, as well as other related family proteins, play a fundamental role in autophagosome biogenesis and maturation by complexing with regulatory modulators such as Beclin1 and the class C protein-sorting aggregated complex.
Novus Biologicals offers NALP4 reagents for your research needs including:
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