CD56 is a member of the Ig super family and comprises five Ig-like domains and two extracellular fibronectin-type III domains. It is expressed as three major isoforms within the nervous system, on NK cells, and a specific set of T-cells. CD56+ NK and T-cells are unique in their ability to mediate cell-mediated cytotoxicity against certain tumor cell targets without MHC restriction. Other CD56 physiological functions include: mediating cell adhesion, triggering neurite extension and migration, and brain synapse formation. CD56 is also crucial for neuronal development and plasticity in the adult brain. It is used as a tumor marker in various cancers (NK lymphomas and Merkel cell carcinoma). As another member of the Ig super family superfamily, NCAM1 consists of five extracellular Ig-like domains and two fibronectin type III domains. It has at least 20-30 distinct isoforms due to alternative splicing and sialylation posttranslational modifications.
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Immunohistochemistry-Paraffin: CD56 + NCAM-1 Antibody
A CD56 + NCAM1 antibody was initially used in Mooi’s lab in the Netherlands Cancer Institute to create histological profiles on a large bank of 350+ resected lung tumors1. This profile typing validated the use of the CD56 + NCAM1 antibody as an identification and characterization tool for the challenging task of distinguishing between the major types of lung cancers. Related studies from the same group relied upon extensive use of the CD56 + NCAM1 antibody in profiles of normal tissues2. These particular studies focused on determining CD56 + NCAM1 antibody reactivity in endocrine and neuron-supporting normal tissues. Studies out of Brezicka’s group employed the CD56 + NCAM1 antibody to detect and differentiate small cell lung cancer (SCLC) from other lung tumor histotypes in patients suspected to have primary lung tumors3.
Novus Biologicals offers CD56 + NCAM-1 reagents for your research needs including:
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