Recently, we at Novus Biologicals added a new phospho-MAP1B (phosphorylated microtubule-associated protein 1B) antibody to our antibody database. MAP1B is a developmentally regulated phosphoprotein thought to be involved in the assembly of microtubules, an essential part of neurogenesis.
Gene knockdown antibodystudies have shown MAP1B plays an important role in the function and development of the nervous system. It may regulate microtubule function, affecting neuronal differentiation and migration, axon growth and growth-cone function. Mutated MAP1B has been implicated in a range of neural disorders including Fragile X syndrome and giant axonal neuropathy.
Antibodystudies have shown MAP1B is phosphorylated by GSK3 beta (glycogen synthase kinase 3beta) at two sites - Thr1265 and Ser1260. Phospho-MAP1B antibody (also – curiously - known as SuperBUGS) detects...