TLR4 Antibody (76B357.1) - BSA Free

TLR4 (Toll-like receptor 4) is a type-1 transmembrane glycoprotein that is a pattern recognition receptor (PRR) belonging to the TLR family (1-3). TLR4 is expressed in many tissues and is most abundantly expressed in the placenta, spleen, and peripheral blood leukocytes (1). Human TLR4 is synthesized as a 839 amino acid (aa) protein containing a signal sequence (1-23 aa), an extracellular domain (ECD) (24-631 aa), a transmembrane domain (632-652 aa), and Toll/interleukin-1 receptor (TIR) cytoplasmic domain (652-839 aa) with a theoretical molecular weight of 95 kDa (3, 4). The ECD contains 21 leucine-rich repeats (LRRs) and has a horseshoe-shaped structure (3, 4). TLR4 requires binding with the co-receptor myeloid differentiation protein 2 (MD2) largely via hydrophilic interactions for proper ligand sensing and signaling (2-4). In general, the TLR family plays a role in activation of innate immunity and responds to a variety of pathogen-associated molecular patterns (PAMPs) (5). TLR4 is specifically responsive to lipopolysaccharide (LPS), which is found on the outer-membrane of most ram-negative bacteria (3-5). Activation of TLR4 requires binding of a ligand, such as LPS to MD2, followed by MD2-LPS complex binding to TLR4, resulting in a partial complex (TLR4-MD2/LPS) (3, 5). To become fully active, two partial complexes must dimerize thereby allowing the TIR domains of TLR4 to bind other adapter molecular and initiate signaling, triggering an inflammatory response and cytokine production (3, 5).

TLR4 signaling occurs through two distinct pathways: The MyD88 (myeloid differentiation primary response gene 88)-dependent pathway and the MyD88-independent (TRIF-dependent, TIR domain-containing adaptor inducing IFN-beta) pathway (3, 5-7). The MyD88-dependent pathway occurs mainly at the plasma membrane and involves the binding of MyD88-adaptor-like (MAL) protein followed by a signaling cascade that results in the activation of transcription factors including nuclear factor-kappaB (NF-kappaB) that promote the secretion of inflammatory molecules and increased phagocytosis (5-7). Conversely, the MyD88-independent pathway occurs after TLR4-MD2 complex internalization in the endosomal compartment. This pathway involves the binding of adapter proteins TRIF and TRIF-related adaptor molecule (TRAM), a signaling activation cascade resulting in IFN regulatory factor 3 (IRF3) translocation into the nucleus, and secretion of interferon-beta (INF-beta) genes and increased phagocytosis (5-7).

Given its expression on immune-related cells and its role in inflammation, TLR4 activation can contribute to various diseases (6-8). For instance, several studies have found that TLR4 activation is associated with neurodegeneration and several central nervous system (CNS) pathologies, including Alzheimer's disease, Parkinson's disease, and Huntington's disease (6, 7). Furthermore, TLR4 mutations have been shown to lead to higher rates of infections and increased susceptibility to sepsis (7-8). One potential therapeutic approach aimed at targeting TLR4 and neuroinflammation is polyphenolic compounds which include flavonoids and phenolic acids and alcohols (8).

Alternative names for TLR4 includes 76B357.1, ARMD10, CD284 antigen, CD284, EC 3.2.2.6, homolog of Drosophila toll, hToll, toll like receptor 4 protein, TOLL, toll-like receptor 4.

References

1. Vaure, C., & Liu, Y. (2014). A comparative review of toll-like receptor 4 expression and functionality in different animal species. Frontiers in immunology. https://doi.org/10.3389/fimmu.2014.00316

2. Park, B. S., & Lee, J. O. (2013). Recognition of lipopolysaccharide pattern by TLR4 complexes. Experimental & molecular medicine. https://doi.org/10.1038/emm.2013.97

3. Krishnan, J., Anwar, M.A., & Choi, S. (2016) TLR4 (Toll-Like Receptor 4). In: Choi S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_592-1

4. Botos, I., Segal, D. M., & Davies, D. R. (2011). The structural biology of Toll-like receptors. Structure. https://doi.org/10.1016/j.str.2011.02.004

5. Lu, Y. C., Yeh, W. C., & Ohashi, P. S. (2008). LPS/TLR4 signal transduction pathway. Cytokine. https://doi.org/10.1016/j.cyto.2008.01.006

6. Leitner, G. R., Wenzel, T. J., Marshall, N., Gates, E. J., & Klegeris, A. (2019). Targeting toll-like receptor 4 to modulate neuroinflammation in central nervous system disorders. Expert opinion on therapeutic targets. https://doi.org/10.1080/14728222.2019.1676416

7. Molteni, M., Gemma, S., & Rossetti, C. (2016). The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation. Mediators of inflammation. https://doi.org/10.1155/2016/6978936

8. Rahimifard, M., Maqbool, F., Moeini-Nodeh, S., Niaz, K., Abdollahi, M., Braidy, N., Nabavi, S. M., & Nabavi, S. F. (2017). Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation. Ageing research reviews. https://doi.org/10.1016/j.arr.2017.02.004

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 6 confirmed species: Human, Mouse, Rat, Bovine, Mammal, Porcine.

We have publications tested in 19 applications: B/N, Chemotaxis, Cytometric Bead Assay Standard, ELISA, FLOW, Flow Cytometry Control, Flow-CS, ICC/IF, IF/IHC, IHC, IHC-Fr, IHC-P, In Vivo, In-vitro, KD, KO, PAGE, Simple Western, WB.

Showing Publications 1 - 10 of 138. Show All 138 Publications. Collapse Publications.

Publications using NB100-56566	Applications	Species
Harris DD, Sabe SA, Xu CM et al. Sodium-glucose co-transporter 2 inhibitor canagliflozin modulates myocardial metabolism and inflammation in a swine model for chronic myocardial ischemia Surgery 2023-11-06 [PMID: 37940431] (WB, Porcine)	WB	Porcine
Zhu Z, Zhang L, Elsherbini A et al. The S1P receptor 1 antagonist Ponesimod reduces TLR4-induced neuroinflammation and increases A? clearance in 5XFAD mice EBioMedicine 2023-07-20 [PMID: 37480622] (IHC, ICC/IF)	IHC, ICC/IF
González A, García-Gómez-Heras S, Franco-Rodríguez R et al. Cisplatin cycles treatment sustains cardiovascular and renal damage involving TLR4 and NLRP3 pathways Pharmacology research & perspectives 2023-08-01 [PMID: 37424158] (WB, IHC-P, Rat)	WB, IHC-P	Rat
Aamir K, Sethi G, Afrin MR et al. Arjunolic acid modulate pancreatic dysfunction by ameliorating pattern recognition receptor and canonical Wnt pathway activation in type 2 diabetic rats Life sciences 2023-08-15 [PMID: 37307966] (Simple Western, IHC, Rat)	Simple Western, IHC	Rat
Sanjurjo L, Castelblanco E, Julve J et al. Contribution of Elevated Glucose and Oxidized LDL to Macrophage Inflammation: A Role for PRAS40/Akt-Dependent Shedding of Soluble CD14 Antioxidants (Basel, Switzerland) 2023-05-11 [PMID: 37237950] (WB, Human)	WB	Human
Zhou M, Pang F, Liao D et al. Electroacupuncture at Fengchi(GB20) and Yanglingquan(GB34) Ameliorates Paralgesia through Microglia-Mediated Neuroinflammation in a Rat Model of Migraine Brain Sciences 2023-03-24 [PMID: 37190506] (WB, IHC)	WB, IHC
Tsioti I, Steiner BL, Escher P et al. Endothelial Toll-like receptor 4 is required for microglia activation in the murine retina after systemic lipopolysaccharide exposure Journal of neuroinflammation 2023-02-04 [PMID: 36739425] (FLOW, Mouse)	FLOW	Mouse
Tabandeh MR, Jozaie S, Ghotbedin Z, Gorani S Dimethyl itaconic acid improves viability and steroidogenesis and suppresses cytokine production in LPS-treated bovine ovarian granulosa cells by regulating TLR4/nfk beta, NLRP3, JNK signaling pathways Research in veterinary science 2022-08-01 [PMID: 35933803] (WB, Bovine)	WB	Bovine
Abd El-Aal SA, AbdElrahman M, Reda AM et al. Galangin Mitigates DOX-induced Cognitive Impairment in Rats: Implication of NOX-1/Nrf-2/HMGB1/TLR4 and TNF-alpha/MAPKs/RIPK/MLKL/BDNF Neurotoxicology 2022-07-14 [PMID: 35843304] (IHC-P, Rat) Details: adult male (8–10 weeks) Wistar rats	IHC-P	Rat
Kang Jy, Lee JS, Seol IC et al. Pharmacological Effects of Gami-yukmijihwang-Tang on the Lipopolysaccharide-Induced Hippocampus Oxidation and Inflammation via Regulation of Sirt6 Pharmaceuticals (Basel, Switzerland) 2022-02-28 [PMID: 35337091] (WB, Mouse)	WB	Mouse
Visioli F, Nunes JS, Pedicillo MC et al. TLR4 Expression in Ex-Lichenoid Lesions-Oral Squamous Cell Carcinomas and Its Surrounding Epithelium: The Role of Tumor Inflammatory Microenvironment Biomolecules 2022-02-28 [PMID: 35327577] (IHC-P, Human)	IHC-P	Human
Deschamps C, Uyttersprot F, Debris M et al. ANTI-INFLAMMATORY DRUGS PREVENT MEMORY AND HIPPOCAMPAL PLASTICITY DEFICITS FOLLOWING INITIAL BINGE-LIKE ALCOHOL EXPOSURE IN ADOLESCENT MALE RATS Psychopharmacology 2022-03-21 [PMID: 35314896]
Zhang C, Wang X, Wang C et al. Qingwenzhike Prescription Alleviates Acute Lung Injury Induced by LPS via Inhibiting TLR4/NF-kB Pathway and NLRP3 Inflammasome Activation Frontiers in Pharmacology 2021-12-23 [PMID: 35002723]
Majumder S, Pushpakumar S, Juin SK et al. Toll-like receptor 4 mutation protects the kidney from Ang-II-induced hypertensive injury Pharmacological research 2021-12-09 [PMID: 34896544] (WB, Mouse)	WB	Mouse
Vilpoux C, Fouquet G, Deschamps C et al. Astrogliosis and compensatory neurogenesis after the first ethanol binge drinking-like exposure in the adolescent rat Alcoholism, clinical and experimental research 2021-12-03 [PMID: 34862633]
Reynolds KE, Krasovska V, Scott AL Converging purinergic and immune signaling pathways drive IL-6 secretion by Fragile X cortical astrocytes via STAT3 Journal of neuroimmunology 2021-10-08 [PMID: 34695768] (WB, Mouse)	WB	Mouse
Niu F, Liao K, Hu G et al. HIV Tat-Mediated Induction of Monocyte Transmigration Across the Blood-Brain Barrier: Role of Chemokine Receptor CXCR3 Frontiers in Cell and Developmental Biology 2021-08-30 [PMID: 34527676] (WB, B/N)	WB, B/N
El-Haija M, Ye Y, Chu Y et al. Toll-like receptor-4 (TLR4) and MyD88 are required for Gastric Bypass-induced metabolic effects Surgery for Obesity and Related Diseases 2021-08-01 [PMID: 34462225] (WB, IHC-P)	WB, IHC-P
Xiao Q, Chen YH, Pratama SA Et al. The Prophylactic Effects of Glutamine on Muscle Protein Synthesis and Degradation in Rats with Ethanol-Induced Liver Damage Nutrients [PMID: 34444950] (WB, Rat)	WB	Rat
Zhong S, Zhou Z, Lin X Et al. Ketogenic diet prevents paclitaxel-induced neuropathic nociception through activation of PPAR gamma signalling pathway and inhibition of neuroinflammation in rat dorsal root ganglion The European journal of neuroscience 2021-08-01 [PMID: 34318540] (WB, Rat)	WB	Rat
Di Cerbo A, Giusti S, Mariotti F et al. Increased Expression of Toll-Like Receptor 4 in Skin of Dogs with Discoid Lupus Erythematous (DLE) Animals : an open access journal from MDPI 2021-04-08 [PMID: 33917661]
Alharbi MO, Dutta B, Goswami R et al. Identification and functional analysis of a biflavone as a novel inhibitor of transient receptor potential vanilloid 4-dependent atherogenic processes Sci Rep 2021-04-15 [PMID: 33854174] Details: Citation using the DyLight 488 format of this antibody.
Liu L, Aron CZ, Grable CM, et al. Surfactant protein A reduces TLR4 and inflammatory cytokine mRNA levels in neonatal mouse ileum Scientific reports 2021-01-28 [PMID: 33510368] (WB, Mouse, Human)	WB	Mouse, Human
Liu J, Li L, Luo N et al. Inflammatory signals induce MUC16 expression in ovarian cancer cells via NF‑kappa B activation Experimental and Therapeutic Medicine 2020-12-21 [PMID: 33456530] (Human) Details: HEY cell lines		Human
Yeh WJ, Tsai CC, Ko J, Yang HY Hylocereus polyrhizus Peel Extract Retards Alcoholic Liver Disease Progression by Modulating Oxidative Stress and Inflammatory Responses in C57BL/6 Mice Nutrients 2020-12-18 [PMID: 33353102] (WB, Mouse)	WB	Mouse
Markarian M, Krattli RP Jr, Baddour JD et al. Glia-Selective Deletion of Complement C1q Prevents Radiation-Induced Cognitive Deficits and Neuroinflammation Cancer Research 2021-04-01 [PMID: 33323383] (ICC/IF)	ICC/IF
Soto-Tinoco E, Santacruz E, Basualdo-Sigales MDC et al. Time-of-Day-Dependent Gating of the Liver-Spinal Axis Initiates an Anti-Inflammatory Reflex in the Rat eNeuro 2020-12-10 [PMID: 33203733] (WB, Rat)	WB	Rat
Lee CY, Park HK, Lee BS et al. Novel Therapeutic Effects of Pterosin B on Ang II-Induced Cardiomyocyte Hypertrophy Molecules 2020-11-12 [PMID: 33198253] (WB, Rat) Details: H9c2 cells treated with Ang II, resulting in hypertrophy, underwent Western blot analysis.	WB	Rat
Khan HU, Aamir K, Jusuf PR et al Lauric acid ameliorates lipopolysaccharide (LPS)-induced liver inflammation by mediating TLR4/MyD88 pathway in Sprague Dawley (SD) rats Life Sci 2020-11-14 [PMID: 33188836] (WB, Mouse) Details: Citation using the Azide Free version of this antibody.	WB	Mouse
Holdbrooks AT, Ankenbauer KE, Hwang J, Bellis SL Regulation of inflammatory signaling by the ST6Gal-I sialyltransferase PLoS One 2020-11-09 [PMID: 33166339] (PAGE)	PAGE
Min WP, Wei XF Nervilifordin F alleviates intestinal ischemia/reperfusion-induced acute lung injury via inhibiting inflammasome and mTOR pathway Auris Nasus Larynx 2020-10-08 [PMID: 33077306] (WB, Rat)	WB	Rat
Chen YL, Shirakawa H, Lu NS et al. Impacts of fish oil on the gut microbiota of rats with alcoholic liver damage J. Nutr. Biochem. 2020-09-10 [PMID: 32920090] (WB, Rat)	WB	Rat
Chivero ET, Liao K, Niu F et al. Engineered Extracellular Vesicles Loaded With miR-124 Attenuate Cocaine-Mediated Activation of Microglia Frontiers in Cell and Developmental Biology 2020-07-30 [PMID: 32850781] (In Vivo)	In Vivo
Bi Y, Ding Y, Wu J Et al. Staphylococcus aureus induces mammary gland fibrosis through activating the TLR/NF-kB and TLR/AP-1 signaling pathways in mice Microb Pathog 2020-08-14 [PMID: 32783982] Details: Citation using the Azide Free version of this antibody.
Seimetz M, Sommer N, Bednorz M et al. NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD Nat Metab 2020-06-01 [PMID: 32694733]
Halder A, Yadav K, Aggarwal A et al. Activation of TNFR1 and TLR4 following oxygen glucose deprivation promotes mitochondrial fission in C6 astroglial cells Cell. Signal. 2020-07-18 [PMID: 32693013] (FLOW, WB, Rat)	FLOW, WB	Rat
Burkovetskaya ME, Small R, Guo L et al. Cocaine self-administration differentially activates microglia in the mouse brain Neurosci. Lett. 2020-04-09 [PMID: 32278944] (WB, Mouse)	WB	Mouse
Ozbek M, Hitit M, Ergun E et al. Expression profile of Toll-like receptor 4 in rat testis and epididymis throughout postnatal development Andrologia 2020-01-31 [PMID: 32003057] (IF/IHC, Rat)	IF/IHC	Rat
Rodet F, Capuz A, Ozcan BA et al. PC1/3 KD Macrophages Exhibit Resistance to the Inhibitory Effect of IL-10 and a Higher TLR4 Activation Rate, Leading to an Anti-Tumoral Phenotype Cells 2019-11-22 [PMID: 31766635] (KD, ICC/IF, Rat)	KD, ICC/IF	Rat
Evran S, Calis F, Akkaya E et al. The effect of high mobility group box-1 protein on cerebral edema, blood-brain barrier, oxidative stress and apoptosis in an experimental traumatic brain injury model Brain Res. Bull. 2019-11-09 [PMID: 31715313] (IF/IHC, Rat)	IF/IHC	Rat
Zi SF, Li JH, Liu L et al. Dexmedetomidine-mediated protection against septic liver injury depends on TLR4/MyD88/NF-kappaB signaling downregulation partly via cholinergic anti-inflammatory mechanisms Int. Immunopharmacol. 2019-09-11 [PMID: 31520992] (WB, Rat)	WB	Rat
Zhang SP, Yang RH, Shang J et al. FOXC1 up-regulates the expression of toll-like receptors in myocardial ischaemia J. Cell. Mol. Med. 2019-09-13 [PMID: 31517441] (WB, Rat, Mouse, Human)	WB	Rat, Mouse, Human
Wang Z, Liu J, Wang L et al. HMGB1 Inhibition Reduced Astrocytic Polarization and Facilitated Axon Growth after Spinal Cord Injury in Rats Through the TLR4/Pi3K/Cdc42 Signaling Pathway papers.ssrn.com 2022-01-01
Ryu K Y, Lee H J et al. Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling. J Neuroinflammation 2019-10-26 [PMID: 31655606] (WB, Mouse)	WB	Mouse
Manago A, Audrito V, Mazzola F et al. Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation Nat Commun 2019-09-11 [PMID: 31511522] (ICC/IF, Human)	ICC/IF	Human
Yang K, Lauritzen KH, Olsen MB et al. Low Cellular NAD+ Compromises Lipopolysaccharide-Induced Inflammatory Responses via Inhibiting TLR4 Signal Transduction in Human Monocytes J. Immunol. 2019-08-19 [PMID: 31427442] (WB, Human)	WB	Human
Arya RP, Arankalle VA Phenotypic analysis of monocytes and CD4+ T cells in hepatitis E patients with or without pregnancy Hum. Immunol. 2019-07-05 [PMID: 31285077] (FLOW, Human)	FLOW	Human
Araldi D, Bogen O, Green PG et al. Role of Nociceptor Toll-like Receptor 4 (TLR4) in Opioid-Induced Hyperalgesia and Hyperalgesic Priming J. Neurosci. 2019-06-17 [PMID: 31209174] (WB, Rat)	WB	Rat
Agrawal M, Rastogi M, Dogra S et al. IL-37 inhibits the maturation of dendritic cells through the IL-1R8-TLR4-NF-kappa b pathway Biochim Biophys Acta Mol Cell Biol Lipids May 21 2019 [PMID: 31125703] (IHC-P, WB, KO, ICC/IF, Mouse)	IHC-P, WB, KO, ICC/IF	Mouse
Bernardini C, Bertocchi M, Zannoni A Constitutive and LPS-stimulated secretome of porcine Vascular Wall-Mesenchymal Stem Cells exerts effects on in vitro endothelial angiogenesis BMC Vet. Res. 2019-04-27 [PMID: 31029157] (FLOW, ICC/IF, Porcine)	FLOW, ICC/IF	Porcine
Liang, L;Shao, W;Shu, T;Zhang, Y;Xu, S;Guo, L;Zhou, Y;Huang, H;Sun, P; Xuezhikang improves the outcomes of cardiopulmonary resuscitation in rats by suppressing the inflammation response through TLR4/NF- kappa B pathway Biomed. Pharmacother. 2019-06-01 [PMID: 30953818] (ICC/IF, Rat)	ICC/IF	Rat
Luo Q, Cheng D, Huang C et al. Improvement of Colonic Immune Function with Soy Isoflavones in High-Fat Diet-Induced Obese Rats Molecules 2019-03-22 [PMID: 30909396] (WB, Rat)	WB	Rat
Bagratuni T, Sklirou AD, Kastritis E et al. Toll-Like Receptor 4 Activation Promotes Multiple Myeloma Cell Growth and Survival Via Suppression of The Endoplasmic Reticulum Stress Factor Chop Sci Rep 2019-03-01 [PMID: 30824741] (WB, Human)	WB	Human
Wang P, Liu BY, Wu MM et al. Moderate prenatal alcohol exposure suppresses the TLR4-mediated innate immune response in the hippocampus of young rats Neurosci. Lett. 2019-01-30 [PMID: 30710662] (WB, Rat)	WB	Rat
Zhang Z, La Placa D, Nguyen T et al. CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes bioRxiv 2018-08-17 [PMID: 30674283] (B/N)	B/N
Prigent A, Gonzales J, Durand T et al. Acute inflammation down-regulates alpha-synuclein expression in enteric neurons Journal of Neurochemistry 2019-03-01 [PMID: 30589944]
Milanesi S, Verzola D, Cappadona F et al. Uric acid and angiotensin II additively promote inflammation and oxidative stress in human proximal tubule cells by activation of toll-like receptor 4 J. Cell. Physiol. 2018-12-10 [PMID: 30536556] (WB, Human)	WB	Human
Lee JY, Joo B, Nam JH et al. An Aqueous Extract of Herbal Medicine ALWPs Enhances Cognitive Performance and Inhibits LPS-Induced Neuroinflammation via FAk/NF-kB Signaling Pathways. Front Aging Neurosci. 2018-09-26 [PMID: 30319390] (WB, Mouse)	WB	Mouse
Mukherjee P, Hough G, Chattopadhyay A et al. Role of Enterocyte Stearoyl Co-A Desaturase-1 in LDLR Null Mice J. Lipid Res. 2018-08-23 [PMID: 30139760] (ELISA, Mouse)	ELISA	Mouse
Choi CH, Kang TH, Song JS et al. Elevated expression of pancreatic adenocarcinoma upregulated factor (PAUF) is associated with poor prognosis and chemoresistance in epithelial ovarian cancer Sci Rep 2018-08-15 [PMID: 30111860] (IF/IHC, Human)	IF/IHC	Human
Bidne kL, kvidera SS, Ross JW et al. Impact of repeated lipopolysaccharide administration on ovarian signaling during the follicular phase of the estrous cycle in post-pubertal pigs. J. Anim. Sci. 2018-07-03 [PMID: 29982469] (WB, Porcine)	WB	Porcine
Bernardini C, Zannoni A, Bertocchi M et al. Water/ethanol extract of Cucumis sativus L. fruit attenuates lipopolysaccharide-induced inflammatory response in endothelial cells. BMC Complement Altern Med. 2018-06-25 [PMID: 29941006] (WB, Porcine)	WB	Porcine
Sun L, Li M, Ma X et al. Inhibiting high mobility group box-1 reduces early spinal cord edema and attenuates astrocyte activation and aquaporin-4 expression after spinal cord injury in rats J. Neurotrauma 2018-06-21 [PMID: 29929431] (WB, Rat)	WB	Rat
Domon Hisanori, Nagai Kosuke, Maekawa Tomoki et al. Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia. Frontiers in Immunology 2018-01-01 [PMID: 29922273] (WB, Mouse)	WB	Mouse
Nie H, Mei Z et al. Bushen recipe and its disassembled prescriptions inhibit inflammation of liver injury associated with Concanavalin A through Toll like receptor 3/9 signaling pathway. Mol Med Rep 2018-01-08 [PMID: 29845244] (WB, Mouse)	WB	Mouse
Wei W, Wan H, Peng X et al. Antiviral effects of Ma Huang Tang against H1N1 influenza virus infection in vitro and in an ICR pneumonia mouse model Biomedicine & Pharmacotherapy 2018-06-01 [PMID: 29710534] (IF/IHC, Mouse)	IF/IHC	Mouse
Bhattacharjee P, Keyel PA. Cholesterol-dependent cytolysins impair pro-inflammatory macrophage responses. Sci Rep 2018-04-24 [PMID: 29691463] (Mouse)		Mouse
Dickson MJ, Hager CL, Al-Shaibi A et al. Impact of heat stress during the follicular phase on porcine ovarian steroidogenic and phosphatidylinositol-3 signaling. J Anim Sci 2018-06-04 [PMID: 29684161]
Chen X, Yan X, Guo L. Inhibitory effect of Patrinia on BRL-3A cell apoptosis through the TLR4/PI3K/AKT/GSK3b and TLR4/P38/JNK signaling pathways. Mol Med Rep. 2018-01-22 [PMID: 29363726] (Rat)		Rat
Sun L, Li M, Ma X et al. Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-kappa B signaling in an IL-6-dependent manner J Neuroinflammation 2017-11-25 [PMID: 29178911] (WB, Rat)	WB	Rat
Nakano Y, Shimazawa M, Ojino K et al. Toll-like receptor 4 inhibitor protects against retinal ganglion cell damage induced by optic nerve crush in mice. J. Pharmacol. Sci. 2017-03-02 [PMID: 28318829] (WB, Mouse)	WB	Mouse
Tobita K, Watanabe I, Saito M. Specific vaginal lactobacilli suppress the inflammation induced by lipopolysaccharide stimulation through downregulation of toll-like receptor 4 expression in human embryonic intestinal epithelial cells. Biosci Microbiota Food Health. 2017-02-28 [PMID: 28243550] (FLOW, Human)	FLOW	Human
Schoniger S, Grafe H, Schoon H. Expression of Toll-like receptors 2, 4 and 6 in different cell populations of the equine endometrium. Veterinary Immunology and Immunopathology. 2017-01-22 [PMID: 28242004]
Camps-Bossacoma M, Perez-Cano FJ, Franch A et al. Effect of a cocoa diet on the small intestine and gut-associated lymphoid tissue composition in an oral sensitization model in rats. The Journal of Nutritional Biochemistry. 2017-01-23 [PMID: 28189917]
Azuma Y, Taniguchi F, Nakamura K et al. Lipopolysaccharide promotes the development of murine endometriosis-like lesions via the nuclear factor-kappa B pathway. Am. J. Reprod. Immunol. 2017-01-31 [PMID: 28138997] (IF/IHC, Mouse)	IF/IHC	Mouse
Rigo-Adrover MD, Franch A, Castell M, Perez-Cano FJ. Preclinical Immunomodulation by the Probiotic Bifidobacterium breve M-16V in Early Life. PLoS ONE. 2016-11-07 [PMID: 27820846] (FLOW, Rat)	FLOW	Rat
Rathod SB, Tripathy AS. TGF- 1 and contact mediated suppression by CD4+ CD25+ CD127 T regulatory cells of patients with self-limiting hepatitis E. Human Immunology 1905-07-08 [PMID: 27720959] (FLOW, Human)	FLOW	Human
Lin SJ, Kuo ML, Hsiao HS, Lee PT, Azithromycin modulates immune response of Human monocyte-derived dendritic cells and CD4(+) T cells Int. Immunopharmacol. 2016-09-21 [PMID: 27664570] (FLOW, Human)	FLOW	Human
Szasz Theodora, Wenceslau Camilla F, Burgess Beth et al. Toll-Like Receptor 4 Activation Contributes to Diabetic Bladder Dysfunction in a Murine Model of Type 1 Diabetes. Diabetes 2016-01-01 [PMID: 27650857] (IF/IHC, Mouse)	IF/IHC	Mouse
Fujita K, Motoki K, Tagawa K et al. HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease. Sci Rep. 2016-08-25 [PMID: 27557632] (WB, Mouse)	WB	Mouse
Burgueno JF, Barba A, Eyre E et al. TLR2 and TLR9 modulate enteric nervous system inflammatory responses to lipopolysaccharide. J Neuroinflammation. 2016-08-19 [PMID: 27538577] (ICC/IF, Rat)	ICC/IF	Rat
Kuramochi M, Izawa T, Pervin M et al. The kinetics of damage-associated molecular patterns (DAMPs) and toll-like receptors during thioacetamide-induced acute liver injury in rats. Exp. Toxicol. Pathol. 2016-08-10 [PMID: 27522298] (WB, Rat)	WB	Rat
Liu J, Zhang J, Ao Y Exosomes derived from regulatory T cells attenuates MPP+-induced inflammatory response and oxidative stress in BV-2 cells by inhibiting the TLR4/NF-kappa B signaling Molecular & Cellular Toxicology 2022-06-21
Chen CW, Chen CC, Jian CY et al. Attenuation of exercise effect on inflammatory responses via novel role of TLR4/PI3K/Akt signaling in rat splenocytes J. Appl. Physiol. 2016-08-18 [PMID: 27539497]
Li XJ, Bao WR, Leung CH et al. Chemical Structure and Immunomodulating Activities of an a-Glucan Purified from Lobelia chinensis Lour. Molecules 2016-06-18 [PMID: 27314319]
Okada K, Arai S, Itoh H et al. CD68 on rat macrophages binds tightly to S100A8 and S100A9 and helps to regulate the cells' immune functions. J. Leukoc. Biol. 2016-06-16 [PMID: 27312849]
Jeon YK, Kim CK, Koh J et al. Pellino-1 confers chemoresistance in lung cancer cells by upregulating cIAP2 through Lys63-mediated polyubiquitination. Oncotarget. 2016-07-05 [PMID: 27248820] (Cytometric Bead Assay Standard, Human)	Cytometric Bead Assay Standard	Human
Mishima Y, Ishihara S, Oka A et al. Decreased Frequency of Intestinal Regulatory CD5+ B Cells in Colonic Inflammation. PLoS ONE. 2016-01-05 [PMID: 26727001] (FLOW, Mouse)	FLOW	Mouse
Plociennikowska A, Zdioruk MI, Traczyk G et al. LPS-induced clustering of CD14 triggers generation of PI(4,5)P2. J. Cell. Sci. 2015-10-07 [PMID: 26446256] (In-vitro, Mouse)	In-vitro	Mouse
Mehmeti M, Allaoui R, Bergenfelz C, Saal LH. Expression of functional toll like receptor 4 in estrogen receptor/progesterone receptor-negative breast cancer. Breast Cancer Research 2015-09-22 [PMID: 26392082] (IHC-P, Human)	IHC-P	Human
Liu L, Wang Y, Cao ZY et al. Up-regulated TLR4 in cardiomyocytes exacerbates heart failure after long-term myocardial infarction. J. Cell. Mol. Med. 2015-08-20 [PMID: 26290459] (WB, IHC-P, ICC/IF, Rat) Details: TLR4 antibody (clone 76B357.1) was used for WB (1:500 dilution), IHC-P (1:100 dilution) and ICC/IF (1:100 dilution) assays on samples from heart tissues of Rat model of chronic heart failure induced by myocardial infarction.	WB, IHC-P, ICC/IF	Rat
Haricharan S, Brown P. TLR4 has a TP53-dependent dual role in regulating breast cancer cell growth Proc. Natl Acad Sci U. [PMID: 26063617] (B/N, Human) Details: Citation using the Azide Free form of this antibody.	B/N	Human
Martin I, Caban-Hernandez K, Figueroa-Santiago O, Espino AM. Fasciola hepatica Fatty Acid Binding Protein Inhibits TLR4 Activation and Suppresses the Inflammatory Cytokines Induced by Lipopolysaccharide In Vitro and In Vivo J. Immunol. 2015-03-16 [PMID: 25780044] (WB, Human)	WB	Human
Zhu W, Zhu N, Bai D et al. The crosstalk between Dectin1 and TLR4 via NF-kB subunits p65/RelB in mammary epithelial cells. Int. Immunopharmacol. 2014-09-16 [PMID: 25239812] (WB, Rat) Details: TLR4 antibody used for WB at 2 ug/ml concentration in experiments involving Rat's primary mammary epithelial cells (MECs). Fig. 1 - TLR4 in primary rat MECs induced with 0.5 uM LPS in DMSO. Fig. 2 - rat MECs treated or not with TLR4 siRNA and/ or LPS.	WB	Rat
Wang Y, Zhang A, Lu S et al. Adenosine 5'-monophosphate-induced hypothermia inhibits the activation of ERK1/2, JNK, p38 and NF-kB in endotoxemic rats. Int. Immunopharmacol. 2014-09-13 [PMID: 25218163] (IHC-P, Rat) Details: TLR4 antibody (clone 76B357.1) used for IHC-P on lung tissue in experiments involving Rat models of 5'-AMP induced hypothermia/AIH and endotoxemia - 10% formalin fixed - paraffin embedded sections, microwave - 10 mM citrate buffer solution pH 6.0 antigen retrieval via 3X3 minutes cycles, endogenous peroxidase blocking with 0.3% hydrogen peroxide in methanol for 30 min, primary used at 1:400 dilutions with 1 hour incubation at 37C, two-step EnVision method detection (Fig. 4 - staining images of lungs with LPS-challenge and AIH intervention)	IHC-P	Rat
Pivoriunas A Extracellular vesicles promote lipid raft formation in human microglia through TLR4, P2X4R, and aVB3/aVB5 signaling pathways Research Square 2022-10-28 (ICC/IF, Human)	ICC/IF	Human
Dill-McFarland KA, Neil KL, Zeng A et al. Hibernation alters the diversity and composition of mucosa-associated bacteria while enhancing antimicrobial defense in the gut of 13-lined ground squirrels. Mol. Ecol. 2014-08-12 [PMID: 25130694] (WB, Mammal)	WB	Mammal
Sussman Daniel A, Santaolalla Rebeca, Bejarano Pablo A et al. In silico and Ex vivo approaches identify a role for toll-like receptor 4 in colorectal cancer. J Exp Clin Cancer Res. 2014-01-01 [PMID: 24887394] (Human)		Human
Wang Y, Weng Y, Shi Y et al. Expression and Functional Analysis of Toll-like Receptor 4 in Human Cervical Carcinoma. J. Membr. Biol. 2014-07-01 [PMID: 24878539] (ICC/IF, IHC-P, Human) Details: IHC-P: Fig 1, Table 1 (Normal cervical epidermal tissue, cervical intraepithelial neoplasia and cervical carcinoma; IF: Fig 2A, B (SiHa, HeLa and C33A cervical cancer cells). Overall, TLR4 was more highly expressed in pathological conditions of the cervix than in normal cervical tissue. Confocal micrscoopy showed that TLR4 localized to the plasma membrane in IF cell line studies. SiHa had higher TLR4 expression than HeLa which had weak TLR4 expression. TLR4 expression was not detected in C33A cells.	ICC/IF, IHC-P	Human
Dumas A, Amiable N, de Rivero Vaccari JP et al. The Inflammasome Pyrin Contributes to Pertussis Toxin-Induced IL-1B Synthesis, Neutrophil Intravascular Crawling and Autoimmune Encephalomyelitis. PLoS Pathog. 2014-05-01 [PMID: 24875775] (WB, Mouse) Details: Fig 4c, d: peritoneal leukocytes	WB	Mouse
Green TL, Santos MF, Ejaeidi AA et al. Toll-like receptor (TLR) expression of immune system cells from metastatic breast cancer patients with circulating tumor cells. Exp Mol Pathol. 2014-08-01 [PMID: 24836676] (FLOW, Human) Details: Citation using the Azide Free format of this antibody.	FLOW	Human
Schuster A, Klotz M, Schwab T et al. Maintenance of the enteric stem cell niche by bacterial lipopolysaccharides? Evidence and perspectives. J. Cell. Mol. Med. 2014-04-30 [PMID: 24780093] (ICC/IF, WB, Mouse) Details: IF: Fig 1A (cells from the small intestine) and Fig 1B, C: (primary enteric neural stem progenitor cells); WB: Fig ID (small intestine and colon). The TLR mAb was used at 0.5 ug/ml for WB and 1 ug/ml for IF.	ICC/IF, WB	Mouse
Degraaf AJ, Zas?ona Z, Bourdonnay E, Peters-Golden M. Prostaglandin E2 reduces Toll-like Receptor 4 Expression in Alveolar Macrophages by Inhibition of Translation. Am. J. Respir. Cell Mol. Biol. 2014-03-06 [PMID: 24601788] (Flow-CS, Rat) Details: This citation used the PE version of this antibody.	Flow-CS	Rat
Lacave-Lapalun JV, Benderitter M, Linard C Flagellin and LPS each restores rat lymphocyte populations after colorectal irradiation J Leukoc Biol. 2014-06-01 [PMID: 24532644] (FLOW, Rat) Details: Citation using the Azide Free format of this antibody.	FLOW	Rat
Verma Rewa, Jung Jong Hyeok, Kim Jae Young. 1,25-Dihydroxyvitamin D3 up-regulates TLR10 while down-regulating TLR2, 4, and 5 in human monocyte THP-1 J Steroid Biochem Mol Biol. 2014 May [PMID: 24373795] (Human) Details: This reference used the Azide Free version of NB100-56566.		Human
Verma Rewa, Jung Jong Hyeok, Kim Jae Young. 1,25-Dihydroxyvitamin D3 up-regulates TLR10 while down-regulating TLR2, 4, and 5 in human monocyte THP-1. J Steroid Biochem Mol Biol. 2014 May [PMID: 24373795] (Human) Details: This reference used the Azide Free version of NB100-56566.		Human
Raso GM, Simeoli R, Iacono A et al. Effects of a Lactobacillus paracasei B21060 based synbiotic on steatosis, insulin signaling and toll-like receptor expression in rats fed a high-fat diet. J. Nutr. Biochem. 2014-01-01 [PMID: 24314869] (WB, Rat) Details: Rat liver, Fig 5B. TLR4 was detected at ~97 kDa. anti-TLR4.	WB	Rat
Kuhn H, Petzold K, Hammerschmidt S et al. Interaction of cyclic mechanical stretch and toll-like receptor 4-mediated innate immunity in rat alveolar type II cells. Respirology 2014-01-01 [PMID: 23796194] (WB, Flow-CS, Rat)	WB, Flow-CS	Rat
Abdi J, Mutis T, Garssen J, Redegeld F. Characterization of the Toll-like receptor expression profile in human multiple myeloma cells. PLoS One. 2013-04-08 [PMID: 23593278] (Flow Cytometry Control, WB) Details: Antibodies cited [multiple myeloma (MM) cell lines, human intestine tissue lysate, PBMC, mouse splenocytes] for WB (Figs 2, 3, 4A, 4B, 5, Table 1) and Flow (Intracellular): Figs 4C, 6-8, Table 1: 1. TLR1 (IMG-5012) 2. TLR2 (IMG-416A)3. TLR3 (IMG-315A)4 TL	Flow Cytometry Control, WB
Semar S, Klotz M, Letiembre M et al. Changes of the enteric nervous system in amyloid-B protein precursor transgenic mice correlate with disease progression. J Alzheimers Dis. 2013-01-01 [PMID: 23531500]
Ramani V, Madhusoodhanan R, Kosanke S et al. A TLR4-interacting SPA4 peptide inhibits LPS-induced lung inflammation. Innate Immun 2013-12-01 [PMID: 23475791] (ICC/IF, Human)	ICC/IF	Human
Tian J, Guo X, Liu XM et al. Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes. Cardiovasc Res. 2013-06-01 [PMID: 23447644] (WB, Rat)	WB	Rat
Jazaeri F, Tavangar SM, Ghazi-Khansari M et al. Cirrhosis is associated with development of tolerance to cardiac chronotropic effect of endotoxin in rats. Liver Int. 2013-03-01 [PMID: 23311391] (IHC-P) Details: IMG-5031A (clone 76B357.1), IHC (P): Fig 3 (rat atrial tissue). TLR4 staining was observed in myocytes and endothelial cells. LPS upregulated TLR4 expression. Human breast tissue was used as positive control.	IHC-P
Wu Y, Lu J, Antony S et al. Activation of TLR4 is required for the synergistic induction of dual oxidase 2 and dual oxidase A2 by IFN-G and lipopolysaccharide in human pancreatic cancer cell lines J Immunol J Immunol. 2013-02-15 [PMID: 23296709] Details: Citation using the Azide Free format of this antibody.
McCulloch L, Brown KL, Mabbott NA. Ablation of the cellular prion protein, PrPC, specifically on follicular dendritic cells has no effect on their maturation or function. Immunology. 2013-03-01 [PMID: 23121447] (IHC-Fr, Mouse) Details: IMG-5031A (clone 76B357.1), IHC (F): 6 (mouse spleen).	IHC-Fr	Mouse
Hsiao CC, Kao YH, Huang SC, Chuang JH. Toll-like receptor-4 agonist inhibits motility and invasion of hepatoblastoma HepG2 cells in vitro. Pediatr Blood Cancer. 2013-02-01 [PMID: 22648929] (IHC-P) Details: TLR4/CD284 (IMG-5031A). IHC (P): Fig 1 (human hepatoblastoma). TLR4 staining was membranous, cytoplasmic and nuclear. TLR4 staining was greatly reduced in liver tissues obtained after chemotherapy treatment.	IHC-P
Zheng YX, Yang M, Rong TT et al. CD74 and macrophage migration inhibitory factor as therapeutic targets in gastric cancer. World J Gastroenterol. 2012-05-14 [PMID: 22611320] (WB, IHC-P, Human)	WB, IHC-P	Human
Liu Y, Fatheree NY, Mangalat N, Rhoads JM. Lactobacillus reuteri strains reduce incidence and severity of experimental necrotizing enterocolitis via modulation of TLR4 and NF-kB signaling in the intestine. Am J Physiol Gastrointest Liver Physiol. 2012-03-15 [PMID: 22207578]
Janardhanam SB, Prakasam S, Swaminathan VT et al. Differential expression of TLR-2 and TLR-4 in the epithelial cells in oral lichen planus. Arch Oral Biol. 2012-05-01 [PMID: 22119043] (IHC-P) Details: IHC (P) of human oral epithelium (Fig 1): 1. TLR2 (IMG-319) 2. TLR4 (IMG-5031A) Note: Both antibodies were used at 0.5/ml. Cutaneous epithelium was used as a positive control for TLR2 and TLR4 expression.	IHC-P
Weile C, Josefsen K, Buschard K. Glucose activation of islets of Langerhans up-regulates Toll-like receptor 5: possible mechanism of protection. Clin Exp Immunol. 2011-11-01 [PMID: 21985371] (WB, Rat) Details: TLR4/CD284 (IMG-5031A) and GAPDH (IMG-3073). WB: Cultured rat islet Langerhans treated with glucose, Fig 1B. Note: TLR4 protein levels were not increased in the presence of glucose activation, Fig 1B.	WB	Rat
Vobeta EV, Skuljec J, Gudi V et al. Characterisation of microglia during de- and remyelination: Can they promote a repair promoting environment Neurobiol Dis 2011-10-06 [PMID: 21971527] (FLOW, Mouse)	FLOW	Mouse
Sweeney TE, Suliman HB, Hollingsworth JW et al. A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis. PLoS One 2011-01-01 [PMID: 21966468] (Chemotaxis)	Chemotaxis
Nowicki M, Kosacka J, Serke H et al. Altered sciatic nerve fiber morphology and endoneural microvessels in mouse models relevant for obesity, peripheral diabetic polyneuropathy, and the metabolic syndrome. J Neurosci Res. 2012-01-01 [PMID: 21919033] (IF/IHC, Mouse) Details: TLR4 IMG-5031A (clone 76B357.1) for IHC (cryostat sections): Fig 5 (dissected mouse nerves). Note: the antibody was used at 1:500. Mice were perfused with 4% formaldehyde in 0.1 M PBS prior to dissection.	IF/IHC	Mouse
Brandau S, Jakob M, Hemeda H et al. Tissue-resident mesenchymal stem cells attract peripheral blood neutrophils and enhance their inflammatory activity in response to microbial challenge. J Leukoc Biol. 2010-11-01 [PMID: 20682625] (FLOW, Human) Details: TLR4 antibody clone 76B357.1 cited for Flow (Cell Surface), Fig 2: human primary parotid mesenchymal stem cell cultures.	FLOW	Human
Hafez M, Hayes K, Goldrick M et al. The K5 capsule of Escherichia coli strain Nissle 1917 is important in stimulating expression of Toll-like receptor 5, CD14, MyD88, and TRIF together with the induction of interleukin-8 expression via the mitogen-activated protein kinase pathway in epithelial cells. Infect Immun. 2010-05-01 [PMID: 20145095] Details: IMGENEX products cited: 1. TLR4 (IMG- 5031A) Flow (Cell surface), Fig 3, Caco-2 cells. 2. TLR5 (IMG-663A) Flow (Cell surface), Fig 2, Fig 3, Caco-2 cells.
Bidne KL. Investigating the ovarian response to endotoxemia. Thesis 1905-07-09 (WB, Porcine)	WB	Porcine
Johnston MJ, Wang A, Catarino ME et al. Extracts of the rat tapeworm, Hymenolepis diminuta, suppress macrophage activation in vitro and alleviate chemically induced colitis in mice. Infect Immun. 2010-03-01 [PMID: 20028812]
Wu J, Meng Z, Jiang M et al. Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific. Immunology. [PMID: 19922426] Details: Citation using the PE/Cy5 form of this antibody.
Nowicki M, Muller K, Serke H et al. Oxidized low-density lipoprotein (oxLDL)-induced cell death in dorsal root ganglion cell cultures depends not on the lectin-like oxLDL receptor-1 but on the toll-like receptor-4. J Neurosci Res. 2010-02-01 [PMID: 19705455] (ICC/IF, Rat) Details: IF: DRG (dorsal root ganglia) cells from ten day postnatal SPRD male rats, Fig 5B.	ICC/IF	Rat
Worku M, Morris A. Binding of different forms of lipopolysaccharide and gene expression in bovine blood neutrophils. J Dairy Sci 2009-07-01 [PMID: 19528595] (FLOW, Bovine) Details: Using the PE conjugated version of NBP2-27149, catalog number NBP2-27149PE.	FLOW	Bovine
O'Hara Steven P, Small Aaron J, Gajdos Gabriella B et al. HIV-1 Tat protein suppresses cholangiocyte toll-like receptor 4 expression and defense against Cryptosporidium parvum. J Infect Dis. 2009-04-15 [PMID: 19265483] (WB)	WB
Link A, Selejan S, Maack C et al. Phosphodiesterase 4 inhibition but not beta-adrenergic stimulation suppresses tumor necrosis factor-alpha release in peripheral blood mononuclear cells in septic shock. Crit Care. 2008-01-01 [PMID: 19091080] Details: TLR4/CD284 (IMG-5031C): Flow (cell surface), human CD14+ monocytes derived from healthy donors stimulated with increasing concentrations of LPS (lipopolysaccharide). 2. TLR2/CD282 (IMG-6320C): Flow (cell surface), human CD14+ monocytes derived from healthy donors stimulated with increasing concentrations of SEB (Staphylococcus aureus enterotoxin).
Lunardi C, Bason C, Dolcino M et al. Antiflagellin antibodies recognize the autoantigens Toll-Like Receptor 5 and Pals 1-associated tight junction protein and induce monocytes activation and increased intestinal permeability in Crohn's disease. J Intern Med. 2009-02-01 [PMID: 18796002] (WB, Human) Details: WB (IMG-5031A): Fig 1a (293T cells transfected with the human TLR4 gene). TLR4 was detected in the TLR4 293T transfected cells (lane 2, ~88 kDa), but not in the untransfected cells (lane 1). TLR4 was observed as an ~88 kDa band in lane 2. Note: The specificity of the antibody was TLR4 transfected validated in Fig 1 by western blot [compare lanes 1 (untransfected) and 2 (TLR4 transfected)].	WB	Human
Cohen PA, Koski GK, Czerniecki BJ et al. STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells. Blood. 2008-09-01 [PMID: 18577706] (ICC/IF, Mouse) Details: Flow (intracellular), mouse bone marrow cells, Fig. 1E: 1. TLR3 FITC (IMG-315C) 2. TLR4 FITC (IMG-417C) 3. TLR7 (IMG-665A) 4. TLR8 FITC (IMG-321C) 5. TLR9 FITC (IMG-305C).	ICC/IF	Mouse
Yoshizaki A, Iwata Y, Komura K et al. CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma. Am J Pathol. 2008-06-01 [PMID: 18467694]
Kessel A, Toubi E, Pavlotzky E et al. Treatment with glutamine is associated with down-regulation of Toll-like receptor-4 and myeloid differentiation factor 88 expression and decrease in intestinal mucosal injury caused by lipopolysaccharide endotoxaemia in a rat. Clin Exp Immunol. 2008-02-01 [PMID: 18070149] (Rat)		Rat
Allam JP, Peng WM, Appel T et al. Toll-like receptor 4 ligation enforces tolerogenic properties of oral mucosal Langerhans cells. J Allergy Clin Immunol. 2008-02-01 [PMID: 18036651] (Flow-CS, Human) Details: Flow (cell surface): Oral mucosa from the vestibular region were obtained from non-tumor and noninflamed human patients, Fig 1C.	Flow-CS	Human
Zanoni G, Navone R, Lunardi C et al. In Celiac Disease, a Subset of Autoantibodies Against Transglutaminase Binds Toll-Like Receptor 4 and Induces Activation of Monocytes PLoS Med 2006-09-01 [PMID: 16984219] (WB)	WB
Show All 138 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	IHC -Frozen	Mouse	05/25/2017	View Summary Application Other Sample Tested brain tissue slice(30um Species Mouse Comments Comments IHC-frozen, 1:500
Enlarge	5 reviewed by: Hayk Simonyan	IHC	Mouse	05/16/2017	View Summary Application Immunohistochemistry Sample Tested Adult mouse brain tissue,Mouse brain,Mouse cortex Species Mouse
Enlarge	4 reviewed by: Aileen Keating	WB	Other	05/12/2016	View Summary Application Western Blot Sample Tested Pig whole ovarian lysate Species Other Lot CTJZUO
Enlarge	4 reviewed by: Liyong Zhang	WB	Mouse	08/07/2014	View Summary Application Western Blot Species Mouse
Enlarge	4 reviewed by: Courtney Kurtz	WB	Other	08/11/2011	View Summary Application Western Blot Sample Tested small intestinal lysate, Sample Amount: 50 ug Species Other

Array NB100-56566

• TLR4 Antibodies
• TLR4 ELISA Kits
• TLR4 Inhibitors
• TLR4 Lysate
• TLR4 Proteins
• TLR4 Proteins and Enzymes